Professor and Director, Center for Motor Control and Disease, East China Normal University
Email: xjin@bio.ecnu.edu.cn
Office: Room 204, Key Laboratory of Brain Functional Genomics, 3663 North Zhongshan Road, Shanghai
Basal ganglia, motor control, sequence learning, action timing, brain-machine interface, Parkinson disease
We interact with the world by acting. Adaptive control of movement is probably the most critical function of the brain through millions of years of evolution. Our team charts the fundamental principles of how the brain learns and controls movements to probe cognition and develop treatments for a wide range of related neurological and psychiatric diseases. Specifically, we focus on a series of subcortical nuclei called basal ganglia, and try to unveil the basic computations of how different cell types and subcircuits mediate the organization of movements into proper order and timing, by a combination of cutting-edge neuro-techniques with multiple levels of analysis.
2007 Ph.D. in Biomedical Engineering, Shanghai Jiao Tong University, China
2002 B.S. in Applied Physics, China Agricultural University, China
2021-present Professor and Director, Center for Motor Control and Disease, East China Normal University, China
2018-2020 Associate Professor, The Salk Institute for Biological Studies, USA
2012-2017 Assistant Professor, The Salk Institute for Biological Studies, USA
2008-2011 Postdoctoral Fellow, National Institutes of Health, USA
2018 McKnight Memory and Cognitive Disorders Award
2012 Ellison Medical Foundation New Scholar in Aging Award
2011 Portuguese Society for Neuroscience Featured Article Award
2011 NIH/NIAAA Benedict J. Latteri Memorial Award
2011 Society for Neuroscience Gruber International Research Award
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Cook JR, Li H, Nguyen B, Huang HH, Mahdavian P, Kirchgessner MA, Strassmann P, Engelhardt M, Callaway EM, Jin X. (2022) Secondary auditory cortex mediates a sensorimotor mechanism for action timing. Nature Neuroscience 25(3): 330-344.
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Hollon NG, Jin X. (2020) Neural implementation of behavioral hierarchy. Neuron 105(3): 402-404.
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Geddes CE, Li H, Jin X. (2018) Optogenetic editing reveals the hierarchical organization of learned action sequences. Cell 174(1): 32-43.
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Howard CD, Li H, Geddes CE, Jin X. (2017) Dynamic nigrostriatal dopamine biases action selection. Neuron 93(6): 1436-1450.
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Smith JB, Klug JR, Ross DL, Howard CD, Hollon NG, Ko VI, Hoffman H, Callaway EM, Gerfen CR, Jin X. (2016) Genetic-based dissection unveils the inputs and outputs of striatal patch and matrix compartments. Neuron 91(5): 1069-1084.
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Jin X, Tecuapetla F, Costa RM. (2014) Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences. Nature Neuroscience 17(3): 423-430.
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Koralek AC*, Jin X*, Long JD, Costa RM, Carmena JM. (2012) Corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills. Nature 483(7389): 331-335. (* Co-first authors)
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Jin X, Costa RM. (2010) Start/stop signals emerge in nigrostriatal circuits during sequence learning. Nature 466(7305): 457-462.