Professor, Key Laboratory of Brain Functional Genomics of Ministry of Education, East China Normal University
Email: xmzhou@bio.ecnu.edu.cn
Phone: 021-6260-4169
Office: Room 206, Key Laboratory of Brain Functional Genomics of Ministry of Education, 3663 North Zhongshan Road, Shanghai
Auditory perception, Auditory cortex, Plasticity, Perceptual training
The primary objective of Professor Zhou’s research is to understand how experience (training) rewires the brain. Specifically, he is employing behavioral, electrophysiological, and molecular techniques to investigate the experience-based plasticity in the auditory cortex of model animals. He is also developing novel training strategies for remediating deficits in cortical information processing. These studies can aid in the development of new treatment strategies for hearing impairment and other neurological disorders, including autism.
1998 Ph.D., Physiology, East China Normal University
2005 – present Professor, East China Normal University
1998 – 2005 Postdoctoral Fellow, University of Missouri-Columbia
- Cheng Y, Chen R, Su B, Zhang G, Sun Y, An P, Fang Y, Zhang Y, Shan Y, de Villers-Sidani É, Wang Y, Zhou X (2023) Pairing with Enriched Sound Exposure Restores Auditory Processing Degraded by an Antidepressant. Journal of Neuroscience. 43:2850-2859.
- Cheng Y, Tang B, Zhang G, An P, Sun Y, Gao M, Zhang Y, Shan Y, Zhang J, Liu Q, Lai CSW, de Villers-Sidani É, Wang Y, Zhou X (2022) Degraded cortical temporal processing in the valproic acid-induced rat model of autism. Neuropharmacology. 209:109000.
- Zhang Y, Zhu M, Sun Y, Tang B, Zhang G, An P, Cheng Y, Shan Y, Merzenich MM, Zhou X (2021) Environmental noise degrades hippocampus-related learning and memory. Proc Natl Acad Sci USA. 118:e2017841117.
- Cheng Y, Zhang Y, Wang F, Jia G, Zhou J, Shan Y, Sun X, Yu L, Merzenich MM, Recanzone GH, Yang L, Zhou X (2020) Reversal of age-related changes in cortical sound-azimuth selectivity with training. Cerebral Cortex. 30:1768-1778.
- Liu X, Wei F, Cheng Y, Zhang Y, Jia G, Zhou J, Zhu M, Shan Y, Sun X, Yu L, Merzenich MM, Lurie DI, Zheng Q, Zhou X (2019) Auditory Training Reverses Lead (Pb)-Toxicity-Induced Changes in Sound-Azimuth Selectivity of Cortical Neurons. Cerebral Cortex. 29:3294-3304.
- Cheng Y, Jia G, Zhang Y, Hao H, Shan Y, Yu L, Sun X, Zheng Q, Kraus N, Merzenich MM, Zhou X (2017) Positive impacts of early auditory training on cortical processing at an older age. Proc Natl Acad Sci USA. 114:6364-6369.
- Zhu X, Liu X, Wei F, Wang F, Merzenich MM, Schreiner CE, Sun X, Zhou X (2016) Perceptual training restores impaired cortical temporal processing due to lead exposure. Cerebral Cortex. 26:334-345.
- Zhou X, Lu YF, Darling RD, Simpson KL, Zhu X, Wang F, Yu L, Sun X, Merzenich MM, Lin RC (2015) Behavioral training reverses global cortical network dysfunction induced by perinatal antidepressant exposure. Proc Natl Acad Sci USA. 112:2233-2238.
- Zhu X, Wang F, Hu H, Sun X, Kilgard MP, Merzenich MM, Zhou X (2014) Environmental acoustic enrichment promotes recovery from developmentally degraded auditory cortical processing. Journal of Neuroscience. 34:5406-5415.
- Zhang Y, Zhao Y, Zhu X, Sun X, Zhou X (2013) Refining cortical representation of sound azimuths by auditory discrimination training. Journal of Neuroscience. 33:9693-9698.
- Zhou X, Merzenich MM (2012) Environmental noise exposure degrades normal listening processes. Nature Communications 10.1038/ncomms1849, 3:843.
- Zhou X, Panizzutti R, de Villers-Sidani E, Madeira C, Merzenich MM (2011) Natural restoration of critical period plasticity in the juvenile and adult primary auditory cortex. Journal of Neuroscience. 31:5625-5634.
- Zhou X, de Villers-Sidani E, Panizzutti R, Merzenich MM (2010) Successive-signal biasing for a learned sound sequence. Proc Natl Acad Sci USA. 107:14839-14844.
- Zhou X, Merzenich MM (2009) Developmentally degraded cortical temporal processing restored by training. Nature Neuroscience.12:26-28.