NYUEast China Normal UniversityNYU Shanghai
mobile

陈爱华

Aihua Chen

华东师范大学脑功能基因组学教育部重点实验室教授

邮箱:ahchen@brain.ecnu.edu.cn

办公电话:021-6223-7102

办公地址:上海市中山北路3663号,华东师范大学脑功能基因组学教育部重点实验室205室

研究领域

多感觉整合,决策,序列,眼动

研究领域简介

灵长类感知与行为实验室:实验室的长期目标是要理解大脑中的神经元回路是如何形成知觉以及知觉如何引导行为。目前的工作重点是将电生理和心理学方法相结合,在灵长类上紧密围绕多模态信息是如何加工整合形成知觉、决策并转化成运动这一过程开展研究。主要研究内容为:

1) 多感觉认知。要在复杂的三维环境中自由活动,个体必须对周围环境中复杂多变的感觉(如视觉、听觉、前庭等)及非感觉(如先验知识等)信息进行动态校正,形成有效的认知进而指导行为。为了对这些信息之间的动态校正机制进行研究,我们以清醒猕猴为研究对象,采用行为学、神经电生理学以及认知神经计算方法来研究虚拟现实环境中的空间朝向认知,并结合微电流刺激和可逆药物失活来了解特定区域神经元在这种多感觉认知中的功能作用。

2) 序列眼动。神经科学的一个根本问题是皮层复杂的神经网络是如何通过学习产生特定的行为。日常生活中,我们常常需要将动作、事件、语言、记忆和思想按一定的方式进行组织。为了探索执行序列任务的神经机制,我们结合清醒猕猴的行为学、电生理记录和分析,以及光遗传技术,来了解特定类型的细胞和环路对序列眼动行为的贡献。

教育背景

2005年 中国科学院上海生命科学院神经生物学博士

2000年 南京大学生物科学与技术系生物学学士

研究、工作经历

2012年至今 华东师范大学脑功能基因组学教育部重点实验室研究员

2010年-2012年 美国华盛顿大学(圣路易斯)医学院解剖学与神经解剖系科研人员 

2005年-2010年 美国华盛顿大学(圣路易斯)医学院 解剖学与神经解剖系博士后研究员

代表性论文
  1. Bin Zhao, Rong Wang, Zhihua Zhu, QianLi Yang*, Aihua Chen*. The computational rules of cross-modality suppression in the visual posterior sylvian area. iScience 2023, 26(6):10673. doi: 910.1016/j.isci.2023.106973. eCollection 2023 Jun 16.
  2. Fu Zeng, Adam Zaidel*, Aihua Chen*. Contrary neuronal recalibration in different multisensory cortical areas. eLife 2023;12:e82895. DOI: https://doi.org/10.7554/eLife.82895.
  3. Ziqi Wu, Aihua Chen*, Xinying Cai*. Neuronal response to reward and luminance in macaque LIP during saccadic choice. Neuroscience Bulletin. 2023, 39(1): 14–28.
  4. Jiawei Zhang, Mingyi Huang, Yong Gu, Aihua Chen*, Yuguo Yu*. Visual-Based Spatial Coordinate Dominates Probabilistic Multisensory Inference in Macaque MST-d Disparity Encoding. Brain Sciences. 2022, 12, 1387.
  5. Jiawei Zhang, Yong Gu, Aihua Chen*, Yuguo Yu*. Unveiling Dynamic System Strategies for Multisensory Processing: From Neuronal Fixed-Criterion Integration to Population Bayesian Inference. Research Volume 2022, Article ID 9787040.
  6. Shir Shalom-Sperber*, Aihua Chen, Adam Zaidel. Rapid cross-sensory adaptation of self-motion perception. Cortex 148:14-30, 2022 (doi: 10.1016/j.cortex.2021.11.018) (IF=4.027)
  7. Jing Jia, Zhen Puyang, Xin Jin*, Aihua Chen*. Dynamic encoding of saccade sequences in primate frontal eye field. J. Physiology 599.22 (2021): pp5061-5084.
  8. Bin Zhao, Yi Zhang, Aihua Chen*. Encoding of vestibular and optic flow cues to self-motion in the posterior Superior Temporal Polysensory area. J. Physiology 559.16 (2021): pp3937-3954.
  9. Aihua Chen, Fu Zeng, Gregory C. DeAngelis, Dora E. Angelaki*.  Dynamics of heading and choice-related signals in the parieto-insular vestibular cortex of macaque monkeys. J. Neuroscience. 41(14): 3254-3265, 2021.
  10. Wen-Hao Zhang, He Wang, Ai-Hua Chen, Yong Gu, Tai Sing Lee, K.Y. Michael Wong*, Si Wu*. Complementary congruent and opposite neurons achieve concurrent multisensory integration and segregation. eLife. 2019; 8:e43753. doi: 10.7554/eLife.43753
  11. Yingying Zhang, Shasha Li, Danqing Jiang and Aihua Chen*. Response properties of interneurons and pyramidal neurons in macaque MSTd and VPS areas during self-motion. Front. Neural Circuits. 12: 105, 2018 (doi: 10.3389/fncir.2018.00105) 
  12. Mengmeng Shao, Gregory C. DeAngelis, Dora E. Angelaki, Aihua Chen*. Clustering of Heading Selectivity and Perception-Related Activity in the Ventral Intraparietal Area. J. Neurophysiol. 119(3): 1113-1126, 2018  
  13. Yingying Zhang, Danqing Jiang, Shasha Li, Peiji Liang, Aihua Chen*. Progress in multisensory integration during self-motion processing, Acta Physiologica Siinica. 69(5): 693-702, 2017 
  14. Aihua Chen, Yong Gu, Sheng Liu, Gregory C. DeAngelis, Dora E. Angelaki*. Evidence for a Causal Contribution of Macaque Vestibular, but not intraparietal, cortex to heading perception. J.Neuroscience. 36(13): 3789-3798, 2016. 
  15. Wenhao Zhang, Aihua Chen, Malte J. Rasch*, Si Wu*. Decentralized multisensory information integration in neural systems. J.Neuroscience. 36(2): 532-547, 2016. 
  16. Tatyana A. Yakusheva, Pablo M. Blazquez, Aihua Chen, Dora E. Angelaki*. Spatiotemporal properties of optic flow and vestibular tuning in the cerebellar nodulus and uvula. J.Neuroscience. 33(38): 15145-15160, 2013. 
  17. Aihua Chen, Gregory C. DeAngelis, Dora E. Angelaki*. Functional Specialization of the Ventral Intraparietal Area for Multisensory Heading Discrimination. J. Neuroscience. 33(8): 3567-3581, 2013. 
  18. Aihua Chen, Gregory C. DeAngelis, Dora E. Angelaki*. Representation of vestibular and visual cues to self-motion in ventral intraparietal cortex. J. Neuroscience. 31(33): 12036-12052, 2011. 
  19. Aihua Chen, Gregory C. DeAngelis, Dora E. Angelaki*. Convergence of vestibular and visual self-motion signals in an area of the posterior sylvian fissure. J. Neuroscience. 31(32): 11617-11627, 2011. 
  20. Aihua Chen, Gregory C. DeAngelis, Dora E. Angelaki*. A comparison of vestibular spatiotemporal tuning in macaque parietoinsular vestibular cortex, ventral intraparietal area, and medial superior temporal area. J. Neuroscience. 31(8): 3082-3094, 2011 
  21. Aihua Chen, Gregory C. DeAngelis, Dora E. Angelaki*. Macaque Parieto-Insular Vestibular Cortex: Responses to self-motion and optic flow. J. Neuroscience. 30(8): 3022-3042, 2010 
  22. Aihua Chen, Yong Gu, Katsumasa Takahashi, Dora E. Angelaki, Gregory C. DeAngelis*. Clustering of self-motion selectivity and visual response properties in Macaque Area MSTd. J. Neurophysiol. 100(5):2669-2683, 2008