Co-Director, NYU-ECNU Institute of Brain and Cognitive Science
Professor, Institute of Brain Functional Genomics, East China Normal University
Director, Key Laboratory of Brain Functional Genomics, East China Normal University
Deputy Director, the Institute of Brain and Education Innovation, East China Normal University
Email: lnlin@brain.ecnu.edu.cn
Phone: 021-6223-3533
Office: Room 210, Key Laboratory of Brain Functional Genomics, 3663 North Zhongshan Road, Shanghai
Neural encoding of learning and memory: Our research focuses on the neural encoding mechanisms of the hippocampus in the process of learning and memory consolidation. We are also interested in the involvement and function of amygdala during different phases of fear memory.
Methodology
1. Multi-channel in vivo electrophysiological recording: for the in vivo electrophysiological recording of large-scale neuronal ensembles
2. Viral tracing of neural circuits: to trace synaptic connections of particular neurons in a certain neural circuit
3. Other methods to modulate neural activities: Optogenetic / Chemogenetic / Pharmacological manipulations
Research directions
1. Interneuronal regulation of hippocampal local field potential oscillations:
Study the in vivo firing profiles of interneurons in the hippocampus and other related brain areas and further investigating their modulation towards hippocampal local field potentials, including theta (4 – 12 Hz), gamma (30 – 80 Hz) and high frequency ripple oscillations (100 – 250 Hz). Our goal is to unveil their contribution in hippocampal learning and memory.
2. Functional heterogeneity of hippocampal pyramidal neurons in neural information encoding:
To investigate the different firing patterns of distinct hippocampal pyramidal neuron subtypes and further demonstrate their physiological function.
3. New method for functional brain activity mapping:
By combining in vivo electrophysiological profiles with static brain mapping, we are developing new methods to mapping dynamic functional brain activity.
4. Wireless transmission system for neural activities:
Develop multi-channel neural activity wireless transmission system based on ultra-low power consumption chip capable of wireless data transmission.
2001 Ph.D. in Physiology, East China Normal University
1994 M.S. in Physiology, East China Normal University
1984 B.S. in Biology, East China Normal University
Professor Longnian Lin, Ph.D., is the director of the Key Laboratory of Brain Functional Genomics, Ministry of Education, and the deputy director at the Institute of Brain and Education Innovation, ECNU. Between 2002 and 2004, he went to a postdoctoral program at the Department of molecular biology at Princeton University. In 2004, he returned to China to preside over the construction of brain coding analysis technology platform and serves as head of brain coding laboratory.
1. Ma X, Zhang Y, Wang L, Li N, Barkai E, Zhang X, Lin L, Xu J. The firing of theta state related septal cholinergic neurons disrupt hippocampal ripple oscillations via muscarinic receptors. J Neurosci. 2020 Apr 29; 40(18):3591–3603.
2. Li Y, Xu J, Liu Y, Zhu J, Liu N, Zeng W, Huang N, Rasch MJ, Jiang H, Gu X, Li X, Luo M, Li C, Teng J, Chen J, Zeng S, Lin L, Zhang X. A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning. Nat Neurosci. 2017 Apr;20(4):559-570.
3. Zhang L, Ma X, Chen G, Barkai E, Lin L. Theta Rhythmic Clock-Like Activity of Single Units in the Mouse Hippocampus. J Neurosci. 2016 Apr 20;36(16):4415-20.
4. Zhang L, Chen G, Niu R, Wei W, Ma X, Xu J, Wang J, Wang Z, Lin L. Hippocampal theta-driving cells revealed by Granger causality. Hippocampus. 2012 Aug; 22(8): 1781-93.
5. Lin L, Chen G, Kuang H, Wang D, Tsien JZ. Neural encoding of the concept of nest in the mouse brain. PNAS (Proceedings of the National Academy of Science) 2007, 104(14):6066-71.
6. Lin L, Osan R, Shoham S, Jin W, Zuo W, Tsien JZ. Identification of network-level coding units for real-time representation of episodic experiences in the hippocampus. PNAS (Proceedings of the National Academy of Science) 2005, 102(17): 6125-6130.