Professor, Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University
Email: hmwang@nbic.ecnu.edu.cn; hw1113@nyu.edu
Phone: 021-6223-5180
Office: Room 306 Old Library Building, 3663 North Zhongshan Road, Shanghai
Molecular and neuronal mechanisms of memory, Memory reconsolidation, Memory reconstruction, Neurodegenerative diseases, Neuroethics
Dr. Wang is interested in understanding the molecular, cellular and circuit processes underlying learning and memory, specifically the retrieval and reconsolidation processes of the long-term memory. Using the state-of-the-art approaches, such as proteomics analysis and optogenetics, her lab has been investigating the role of CamKII signaling pathway in memory processes in mice. She is also trying to figure out the neuronal mechanisms of memory reconsolidation in human subjects by using fMRI study. Her lab is also working on the immunomodulatory mechanisms of neurodegenerative diseases, such as Alzheimer’s disease. With the great advances in neuroscience, unprecedented ethical issues have been raised. Her neuroethical team is focusing on the underlying value and ethical concerns with the use of new neuroscientific technology and innovation as well as the cognitive enhancement, especially the impact of Chinese cultural context on these issues.
1999 Ph.D., Dept. of Pharmacology, Rutgers University and Robert-Wood- Johnson Medical School, New Jersey, USA
1988 M.D., Medical School of Zhejiang University, Hangzhou, China
Dr. Wang graduated from the Medical School of Zhejiang University in 1988 and became a pediatrician in the Children’s Hospital affiliated to the Medical School of Zhejiang University. During her post-doctoral training at Princeton University with Dr. Joe Z. Tsien, she developed an in vivo protein knock out technology and studied the molecular signals during different stages of memory processes (1999-2004). Prior to joining East China Normal University, she worked at Boston University as a visiting Scholar.
- Shen F, Chen X, Li J, Cao W, Ku Y, Wu J, Cui Y, Wang Z*, Wang H*, Kwok SC*. (2019). Mnemonic Vulnerability Induced by Post-activation Time-dependent New-learning. Neurobiol Learn Mem. Volume 164: 2019.107047
- Cao T, Zhou X, Zheng X, Cui Y, Tsien JZ, Li CX*, Wang H*. Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice. Front. Aging Neurosci., 15 May 2018
- Jiang M, Liu L, He X, Wang H, Lin W, Wang H, Yoon SO, Wood TL, Lu QR. Regulation of PERK-eIF2α Signalling by Tuberous Sclerosis Complex-1 Controls Homoeostasis and Survival of Myelinating Oligodendrocytes. Nat Commun. 15;7:12185, 2016
- C. Li, S. Dong, H. Wang* and Y. Hu*. Microarray Analysis of Gene Expression Changes in the Brains of NR2B-indiced Memory-enhanced Mice. Neuroscience Vol197:121, 2011
- X. Cao*, H. Wang*, B. Mei*, S. An, L. Yin, L. P. Wang and J. Z. Tsien. Inducible and Selective Erasure of Memories in the Mouse Brain via Chemical-Genetic Manipulation. Neuron Vol 60: 353-366, 2008
- H. Wang*, R. Feng*, L. P. Wang, F. Li, X. Cao and J. Z. Tsien. CaMKII Activation State Underlies Synaptic Labile Phase of LTP and Short-Term Memory Formation. Curr. Biol. Vol 18: 1540-154, 2008
- H. Wang*, E. Shimizu*, Y.-P. Tang*, M. Cho, M. Kyin, W. Zuo, D. A. Robinson, P. J. Alaimo, C. Zhang, H. Morimoto, M. Zhuo, R. Feng, K. M. Shokat and J. Z. Tsien. Inducible Protein Knockout Reveals Temporal Requirement of CaMKII Reactivation for Memory Consolidation in the Brain. Proc. Natl. Acad. Sci. U. S. A. Vol 100:4287-4292, 2003